相互作用
Indomethacin + Ketorolac
重症度: 併用禁忌
Indomethacin and Ketorolac: contraindicated interaction.
最終更新日
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概要
Ketorolac labelling prohibits its use with other NSAIDs, including indomethacin. Two NSAIDs together add to gastrointestinal ulceration and bleeding, renal impairment and platelet inhibition without extra analgesic benefit.
この相互作用をわかりやすく説明すると
Indomethacin and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Indomethacin belongs to Musculoskeletal; Ketorolac belongs to Musculoskeletal.
なぜ起こるのか
Additive COX inhibition (gastrointestinal, renal and antiplatelet toxicity)
対処法
Do not combine; use ketorolac alone for its short course (5 days maximum) or indomethacin alone, not both.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、IndomethacinとKetorolacの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Indomethacinのその他の相互作用
Ketorolacのその他の相互作用
よくある質問
Can I take Indomethacin with Ketorolac?
MediHelp rates the interaction as contraindicated. Indomethacin and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac labelling prohibits its use with other NSAIDs, including indomethacin. Two NSAIDs together add to gastrointestinal ulceration and bleeding, renal impairment and platelet inhibition without extra analgesic benefit.
How serious is the interaction between Indomethacin and Ketorolac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use ketorolac alone for its short course (5 days maximum) or indomethacin alone, not both.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac intranasal, Aceclofenac, Acemetacin. The full list is on the Indomethacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
