相互作用
Isocarboxazid + Nortriptyline
重症度: 併用禁忌
Isocarboxazid and Nortriptyline: contraindicated interaction.
最終更新日
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概要
Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and nortriptyline is a tricyclic antidepressant that blocks noradrenaline and serotonin reuptake. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
この相互作用をわかりやすく説明すると
Isocarboxazid and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
なぜ起こるのか
Excess serotonergic activity (MAO inhibition plus serotonin reuptake or receptor effects)
対処法
Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting nortriptyline, and at least 14 days after stopping nortriptyline before starting isocarboxazid.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、IsocarboxazidとNortriptylineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Nortriptylineのその他の相互作用
Isocarboxazidのその他の相互作用
よくある質問
Can I take Isocarboxazid with Nortriptyline?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and nortriptyline is a tricyclic antidepressant that blocks noradrenaline and serotonin reuptake. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
How serious is the interaction between Isocarboxazid and Nortriptyline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting nortriptyline, and at least 14 days after stopping nortriptyline before starting isocarboxazid.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
