相互作用
Itraconazole + Voclosporin
重症度: 併用禁忌
Itraconazole and Voclosporin: contraindicated interaction.
最終更新日
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概要
Itraconazole markedly raises voclosporin levels, increasing risks of nephrotoxicity, hypertension, neurotoxicity and QT prolongation. Voclosporin labeling contraindicates strong CYP3A4 inhibitors.
この相互作用をわかりやすく説明すると
Itraconazole and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Itraconazole belongs to Anti Fungals; Voclosporin belongs to Miscellaneous.
なぜ起こるのか
Strong CYP3A4 inhibition by itraconazole reduces metabolism of voclosporin, with possible additive QT effects.
対処法
Avoid the combination and use an alternative antifungal with less CYP3A4 inhibition, monitoring renal function if unavoidable exposure occurs.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、ItraconazoleとVoclosporinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Itraconazoleのその他の相互作用
Voclosporinのその他の相互作用
よくある質問
Can I take Itraconazole with Voclosporin?
MediHelp rates the interaction as contraindicated. Itraconazole and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole markedly raises voclosporin levels, increasing risks of nephrotoxicity, hypertension, neurotoxicity and QT prolongation. Voclosporin labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Itraconazole and Voclosporin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antifungal with less CYP3A4 inhibition, monitoring renal function if unavoidable exposure occurs.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
