相互作用
Lefamulin + Pimavanserin
重症度: 併用禁忌
Lefamulin and Pimavanserin: contraindicated interaction.
最終更新日
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概要
Lefamulin inhibits CYP3A4 and raises exposure to CYP3A substrates, and it also prolongs the QT interval. Pimavanserin is a CYP3A4 substrate that itself prolongs QT, so the combination increases the risk of torsades de pointes. Lefamulin labeling contraindicates the oral form with QT-prolonging CYP3A substrates.
この相互作用をわかりやすく説明すると
Lefamulin and Pimavanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lefamulin belongs to Anti Bacterial; Pimavanserin belongs to Central Nervous System.
なぜ起こるのか
CYP3A4 inhibition raises pimavanserin exposure, and both drugs have additive QT-prolonging effects.
対処法
Avoid the combination and choose an antibiotic without QT or CYP3A4 effects. If unavoidable, ECG and electrolyte monitoring are needed with pimavanserin dose reduction.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、LefamulinとPimavanserinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Pimavanserinのその他の相互作用
Lefamulinのその他の相互作用
よくある質問
Can I take Lefamulin with Pimavanserin?
MediHelp rates the interaction as contraindicated. Lefamulin and Pimavanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lefamulin inhibits CYP3A4 and raises exposure to CYP3A substrates, and it also prolongs the QT interval. Pimavanserin is a CYP3A4 substrate that itself prolongs QT, so the combination increases the risk of torsades de pointes. Lefamulin labeling contraindicates the oral form with QT-prolonging CYP3A substrates.
How serious is the interaction between Lefamulin and Pimavanserin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antibiotic without QT or CYP3A4 effects. If unavoidable, ECG and electrolyte monitoring are needed with pimavanserin dose reduction.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Pimozide, Vandetanib, Adagrasib. The full list is on the Pimavanserin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
