相互作用
Leflunomide + Oteseconazole
重症度: 中等度
Leflunomide and Oteseconazole: moderate interaction.
最終更新日
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概要
Oteseconazole inhibits BCRP and may increase teriflunomide concentrations. This could raise the risk of hepatotoxicity and other leflunomide toxicities.
この相互作用をわかりやすく説明すると
Leflunomide and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leflunomide belongs to Musculoskeletal; Oteseconazole belongs to Anti Fungals.
なぜ起こるのか
Oteseconazole inhibits BCRP-mediated transport of teriflunomide.
対処法
Monitor liver enzymes and for adverse effects. Reduce the leflunomide dose if toxicity develops.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LeflunomideとOteseconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Leflunomideのその他の相互作用
Oteseconazoleのその他の相互作用
よくある質問
Can I take Leflunomide with Oteseconazole?
MediHelp rates the interaction as moderate. Leflunomide and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oteseconazole inhibits BCRP and may increase teriflunomide concentrations. This could raise the risk of hepatotoxicity and other leflunomide toxicities.
How serious is the interaction between Leflunomide and Oteseconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and for adverse effects. Reduce the leflunomide dose if toxicity develops.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
