相互作用
Letermovir + Pitavastatin
重症度: 重大
Letermovir and Pitavastatin: major interaction.
最終更新日
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概要
Letermovir increases pitavastatin concentrations, and the effect is magnified when cyclosporine is also given. This raises the risk of myopathy and rhabdomyolysis.
この相互作用をわかりやすく説明すると
Letermovir and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Letermovir belongs to Anti Virals; Pitavastatin belongs to Cardiovascular.
なぜ起こるのか
Letermovir inhibits hepatic uptake transporters OATP1B1/3, raising pitavastatin exposure.
対処法
Avoid coadministration where possible; it is contraindicated if cyclosporine is also used. Otherwise, consider holding the statin during letermovir therapy and monitor for muscle toxicity.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LetermovirとPitavastatinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Pitavastatinのその他の相互作用
Letermovirのその他の相互作用
よくある質問
Can I take Letermovir with Pitavastatin?
MediHelp rates the interaction as major. Letermovir and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir increases pitavastatin concentrations, and the effect is magnified when cyclosporine is also given. This raises the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Letermovir and Pitavastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible; it is contraindicated if cyclosporine is also used. Otherwise, consider holding the statin during letermovir therapy and monitor for muscle toxicity.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
