相互作用
Levothyroxine + Teduglutide
重症度: 中等度
Levothyroxine and Teduglutide: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Teduglutide improves intestinal absorption of fluid and nutrients, which may increase absorption of oral levothyroxine. This could raise thyroid hormone exposure and cause signs of over-replacement in patients with short bowel syndrome.
この相互作用をわかりやすく説明すると
Levothyroxine and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levothyroxine belongs to Endocrine; Teduglutide belongs to Endocrine.
なぜ起こるのか
Teduglutide has intestinotrophic effects that enhance gastrointestinal absorption of orally administered drugs.
対処法
Monitor TSH and free T4 after starting teduglutide and after dose changes. Reduce the levothyroxine dose if over-replacement develops.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LevothyroxineとTeduglutideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Levothyroxineのその他の相互作用
Teduglutideのその他の相互作用
よくある質問
Can I take Levothyroxine with Teduglutide?
MediHelp rates the interaction as moderate. Levothyroxine and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teduglutide improves intestinal absorption of fluid and nutrients, which may increase absorption of oral levothyroxine. This could raise thyroid hormone exposure and cause signs of over-replacement in patients with short bowel syndrome.
How serious is the interaction between Levothyroxine and Teduglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor TSH and free T4 after starting teduglutide and after dose changes. Reduce the levothyroxine dose if over-replacement develops.
What other medicines interact with Levothyroxine?
MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Sodium iodide i-131, Tiratricol. The full list is on the Levothyroxine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
