相互作用
Lonafarnib + Lorlatinib
重症度: 併用禁忌
Lonafarnib and Lorlatinib: contraindicated interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Lorlatinib induces CYP3A4, and lonafarnib is a sensitive CYP3A4 substrate. Lowered lonafarnib exposure may reduce its benefit, and labeling contraindicates its use with CYP3A inducers.
この相互作用をわかりやすく説明すると
Lonafarnib and Lorlatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lonafarnib belongs to Miscellaneous; Lorlatinib belongs to Oncology.
なぜ起こるのか
Lorlatinib induces CYP3A4 and speeds lonafarnib metabolism.
対処法
Avoid the combination and consider an alternative to lorlatinib. Seek specialist advice if both are essential.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LonafarnibとLorlatinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Lorlatinibのその他の相互作用
Lonafarnibのその他の相互作用
よくある質問
Can I take Lonafarnib with Lorlatinib?
MediHelp rates the interaction as contraindicated. Lonafarnib and Lorlatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lorlatinib induces CYP3A4, and lonafarnib is a sensitive CYP3A4 substrate. Lowered lonafarnib exposure may reduce its benefit, and labeling contraindicates its use with CYP3A inducers.
How serious is the interaction between Lonafarnib and Lorlatinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider an alternative to lorlatinib. Seek specialist advice if both are essential.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
