相互作用
Losartan + Selexipag
重症度: 中等度
Losartan and Selexipag: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Selexipag is cleared by CYP2C8 to its active metabolite, and inhibitors of this enzyme may increase exposure. Higher exposure may cause more headache, diarrhea, jaw pain, and hypotension.
この相互作用をわかりやすく説明すると
Losartan and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Losartan belongs to Cardiovascular; Selexipag belongs to Cardiovascular.
なぜ起こるのか
Possible inhibition of CYP2C8-mediated selexipag metabolism.
対処法
Monitor for prostacyclin-related adverse effects and blood pressure. Follow selexipag labeling on dosing frequency with moderate CYP2C8 inhibitors.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LosartanとSelexipagの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Losartanのその他の相互作用
Selexipagのその他の相互作用
よくある質問
Can I take Losartan with Selexipag?
MediHelp rates the interaction as moderate. Losartan and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selexipag is cleared by CYP2C8 to its active metabolite, and inhibitors of this enzyme may increase exposure. Higher exposure may cause more headache, diarrhea, jaw pain, and hypotension.
How serious is the interaction between Losartan and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for prostacyclin-related adverse effects and blood pressure. Follow selexipag labeling on dosing frequency with moderate CYP2C8 inhibitors.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
