相互作用
Magnesium sulfate + Vecuronium
重症度: 重大
Magnesium sulfate and Vecuronium: major interaction.
最終更新日
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概要
Parenteral magnesium sulfate potentiates non-depolarizing neuromuscular blockers, giving a faster onset, deeper block and longer recovery. This can lead to prolonged paralysis and respiratory depression.
この相互作用をわかりやすく説明すると
Magnesium sulfate and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Magnesium reduces presynaptic acetylcholine release and decreases postsynaptic sensitivity, adding to competitive blockade by vecuronium.
対処法
Reduce the vecuronium dose and titrate with quantitative train-of-four monitoring in patients receiving magnesium. Be prepared for delayed recovery and ventilatory support, and check serum magnesium.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Magnesium sulfateとVecuroniumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Vecuroniumのその他の相互作用
よくある質問
Can I take Magnesium sulfate with Vecuronium?
MediHelp rates the interaction as major. Magnesium sulfate and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Parenteral magnesium sulfate potentiates non-depolarizing neuromuscular blockers, giving a faster onset, deeper block and longer recovery. This can lead to prolonged paralysis and respiratory depression.
How serious is the interaction between Magnesium sulfate and Vecuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the vecuronium dose and titrate with quantitative train-of-four monitoring in patients receiving magnesium. Be prepared for delayed recovery and ventilatory support, and check serum magnesium.
What other medicines interact with Vecuronium?
MediHelp also lists interactions of Vecuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Vecuronium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
