相互作用
Colistin + Vecuronium
重症度: 重大
Colistin and Vecuronium: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Colistin can itself cause neuromuscular blockade and may potentiate vecuronium. Prolonged paralysis and respiratory failure are possible.
この相互作用をわかりやすく説明すると
Colistin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colistin belongs to Anti Bacterial; Vecuronium belongs to Musculoskeletal.
なぜ起こるのか
Colistin reduces presynaptic acetylcholine release and stabilizes the postsynaptic membrane, adding to nicotinic blockade by vecuronium.
対処法
Avoid co-administration where possible; otherwise reduce vecuronium dose and monitor with train-of-four. Have ventilatory support available, as reversal may be incomplete.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ColistinとVecuroniumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Vecuroniumのその他の相互作用
Colistinのその他の相互作用
よくある質問
Can I take Colistin with Vecuronium?
MediHelp rates the interaction as major. Colistin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Colistin can itself cause neuromuscular blockade and may potentiate vecuronium. Prolonged paralysis and respiratory failure are possible.
How serious is the interaction between Colistin and Vecuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-administration where possible; otherwise reduce vecuronium dose and monitor with train-of-four. Have ventilatory support available, as reversal may be incomplete.
What other medicines interact with Vecuronium?
MediHelp also lists interactions of Vecuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Vecuronium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
