相互作用
Mercaptopurine + Smallpox vaccine live
重症度: 併用禁忌
Mercaptopurine and Smallpox vaccine live: contraindicated interaction.
最終更新日
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概要
Live vaccinia vaccine can cause progressive vaccinia and generalized infection in immunosuppressed people. Mercaptopurine increases this risk and reduces the protective response.
この相互作用をわかりやすく説明すると
Mercaptopurine and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Immunosuppression from a purine antimetabolite permits uncontrolled replication of vaccinia virus and impairs immune response.
対処法
Avoid live smallpox vaccine in patients on mercaptopurine except in a true exposure emergency under specialist guidance. A non-replicating alternative should be considered where available.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MercaptopurineとSmallpox vaccine liveの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Mercaptopurineのその他の相互作用
よくある質問
Can I take Mercaptopurine with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Mercaptopurine and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live vaccinia vaccine can cause progressive vaccinia and generalized infection in immunosuppressed people. Mercaptopurine increases this risk and reduces the protective response.
How serious is the interaction between Mercaptopurine and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live smallpox vaccine in patients on mercaptopurine except in a true exposure emergency under specialist guidance. A non-replicating alternative should be considered where available.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
