相互作用
Azathioprine + Mercaptopurine
重症度: 併用禁忌
Azathioprine and Mercaptopurine: contraindicated interaction.
最終更新日
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概要
Azathioprine is converted in the body to mercaptopurine, so giving both drugs duplicates the same active thiopurine exposure. This raises the risk of profound myelosuppression, serious infection and hepatotoxicity.
この相互作用をわかりやすく説明すると
Azathioprine and Mercaptopurine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azathioprine belongs to Gastrointestinal Tract; Mercaptopurine belongs to Oncology.
なぜ起こるのか
Therapeutic duplication: azathioprine is a prodrug of mercaptopurine, so both generate the same cytotoxic thioguanine nucleotides.
対処法
Do not combine the two drugs; use only one thiopurine at a time. If switching, stop one before starting the other and monitor blood counts.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、AzathioprineとMercaptopurineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Mercaptopurineのその他の相互作用
Azathioprineのその他の相互作用
よくある質問
Can I take Azathioprine with Mercaptopurine?
MediHelp rates the interaction as contraindicated. Azathioprine and Mercaptopurine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Azathioprine is converted in the body to mercaptopurine, so giving both drugs duplicates the same active thiopurine exposure. This raises the risk of profound myelosuppression, serious infection and hepatotoxicity.
How serious is the interaction between Azathioprine and Mercaptopurine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine the two drugs; use only one thiopurine at a time. If switching, stop one before starting the other and monitor blood counts.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Mercaptopurine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
