相互作用
Metformin + Trilaciclib
重症度: 重大
Metformin and Trilaciclib: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Trilaciclib inhibits renal transporters involved in metformin elimination and can raise metformin exposure. This increases the risk of metformin toxicity, including lactic acidosis.
この相互作用をわかりやすく説明すると
Metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metformin belongs to Endocrine; Trilaciclib belongs to Oncology.
なぜ起こるのか
Trilaciclib inhibits OCT2, MATE1 and MATE2-K, decreasing renal secretion of metformin.
対処法
Avoid metformin on the days of trilaciclib administration if possible, or monitor closely for lactic acidosis and adjust metformin dose. Check renal function beforehand.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MetforminとTrilaciclibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Metforminのその他の相互作用
Trilaciclibのその他の相互作用
よくある質問
Can I take Metformin with Trilaciclib?
MediHelp rates the interaction as major. Metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilaciclib inhibits renal transporters involved in metformin elimination and can raise metformin exposure. This increases the risk of metformin toxicity, including lactic acidosis.
How serious is the interaction between Metformin and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid metformin on the days of trilaciclib administration if possible, or monitor closely for lactic acidosis and adjust metformin dose. Check renal function beforehand.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
