相互作用
Methyldopa + Pexidartinib
重症度: 重大
Methyldopa and Pexidartinib: major interaction.
最終更新日
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概要
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and methyldopa is also a recognised cause of hepatotoxicity. Using both together may raise the likelihood or severity of liver injury.
この相互作用をわかりやすく説明すると
Methyldopa and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methyldopa belongs to Cardiovascular; Pexidartinib belongs to Oncology.
なぜ起こるのか
Additive hepatotoxicity from two drugs that can independently injure the liver.
対処法
Avoid the combination where possible and choose another antihypertensive. If used together, monitor liver enzymes and bilirubin closely and stop the offending drug if liver injury develops.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MethyldopaとPexidartinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Methyldopaのその他の相互作用
Pexidartinibのその他の相互作用
よくある質問
Can I take Methyldopa with Pexidartinib?
MediHelp rates the interaction as major. Methyldopa and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and methyldopa is also a recognised cause of hepatotoxicity. Using both together may raise the likelihood or severity of liver injury.
How serious is the interaction between Methyldopa and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose another antihypertensive. If used together, monitor liver enzymes and bilirubin closely and stop the offending drug if liver injury develops.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Iobenguane i, Lofexidine. The full list is on the Methyldopa page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
