相互作用
Methyldopa + Thioridazine
重症度: 重大
Methyldopa and Thioridazine: major interaction.
最終更新日
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概要
Thioridazine has strong alpha-blocking and sedative activity that can produce marked additive hypotension with methyldopa. Thioridazine also carries a significant risk of QT prolongation, which adds to the concern in patients with cardiovascular disease. The interaction is mainly hemodynamic.
この相互作用をわかりやすく説明すると
Methyldopa and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methyldopa belongs to Cardiovascular; Thioridazine belongs to Central Nervous System.
なぜ起こるのか
Additive hypotension from alpha-1 blockade and central sympatholytic effects, with possible dopaminergic antagonism.
対処法
Avoid if possible, preferring an antipsychotic with less alpha-blockade and QT risk. If combined, monitor blood pressure and ECG closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MethyldopaとThioridazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Methyldopaのその他の相互作用
Thioridazineのその他の相互作用
よくある質問
Can I take Methyldopa with Thioridazine?
MediHelp rates the interaction as major. Methyldopa and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thioridazine has strong alpha-blocking and sedative activity that can produce marked additive hypotension with methyldopa. Thioridazine also carries a significant risk of QT prolongation, which adds to the concern in patients with cardiovascular disease. The interaction is mainly hemodynamic.
How serious is the interaction between Methyldopa and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, preferring an antipsychotic with less alpha-blockade and QT risk. If combined, monitor blood pressure and ECG closely.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Iobenguane i, Lofexidine. The full list is on the Methyldopa page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
