医薬品リファレンス
Methyldopa
Methyldopa is a medicine in the class cardiovascular. It is used for hypertension.
- 薬効分類: Cardiovascular
- 効能・効果: hypertension
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Cardiovascular
- 一般的な剤形
- 錠剤
- 一般的な規格
- 250 mg, 500 mg
- 既知の相互作用
- 92 (併用禁忌: 1 · 重大: 5 · 中等度: 82 · 軽度: 4)
- 商品名
- 15
- 国・市場
- 4
何に使われるか
作用のしくみ
Methyldopa may lower blood pressure by stimulating central inhibitory alpha-adrenergic receptors, false neurotransmission, and/or reduction of plasma renin activity.
成人の通常用量（添付文書の要約）
Hypertension (Initial): 250 mg PO q8-12hr for 2 days, increase q2Days PRN
妊娠と授乳
- 妊娠
- Safe Decades of use in all trimesters without fetal harm; treated hypertensive pregnancies had better outcomes. Starting at 16 to 20 weeks was linked to a slightly smaller head size, with no effects at follow-up. An option for high blood pressure in pregnancy; NICE prefers labetalol, then nifedipine.
- 授乳
- Safe Passes into milk in small amounts that are not expected to affect the infant; LactMed: no special precautions. US label: use with caution. NICE advises stopping methyldopa within 2 days after the birth and changing to another antihypertensive.
報告されている副作用
- Dizziness
- Bradycardia
- Angina
- Orthostatic hypotension
- Depression
- Lethargy
禁忌
- Active liver disease, liver disorders associated with previous methyldopa treatment
- Hypersensitivity to methyldopa or other ingredients (eg, sulfites)
- Pheochromocytoma
注意が必要な方
- May impair ability to perform hazardous tasks
- Interferes with some lab tests
- IM/SC NOT recommended due to erratic absorption
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (92)
- Methyldopa + Tranylcypromine Contraindicated
- Iobenguane i + Methyldopa Major
- Lofexidine + Methyldopa Major
- Methyldopa + Pexidartinib Major
- Methyldopa + Pretomanid Major
- Methyldopa + Thioridazine Major
- Adrenaline-articaine + Methyldopa Moderate
- Apomorphine + Methyldopa Moderate
- Aripiprazole + Methyldopa Moderate
- Benperidol + Methyldopa Moderate
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Methyldopaの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Methyldopa used for?
Methyldopa is a medicine in the class cardiovascular. It is used for Hypertension.
What side effects have been reported with Methyldopa?
Dizziness, Bradycardia, Angina, Orthostatic hypotension, Depression, Lethargy.
Can Methyldopa be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Decades of use in all trimesters without fetal harm; treated hypertensive pregnancies had better outcomes. Starting at 16 to 20 weeks was linked to a slightly smaller head size, with no effects at follow-up. An option for high blood pressure in pregnancy; NICE prefers labetalol, then nifedipine. Breastfeeding: Safe. Passes into milk in small amounts that are not expected to affect the infant; LactMed: no special precautions. US label: use with caution. NICE advises stopping methyldopa within 2 days after the birth and changing to another antihypertensive.
What does Methyldopa interact with?
MediHelp lists 92 known interactions for Methyldopa. Contraindicated: 1 · Major: 5 · Moderate: 82 · Minor: 4. The most serious include Tranylcypromine, Iobenguane i, Lofexidine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
