相互作用
Minocycline + Pexidartinib
重症度: 重大
Minocycline and Pexidartinib: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and minocycline can rarely cause hepatotoxicity as well. Using both may add to the risk of liver damage.
この相互作用をわかりやすく説明すると
Minocycline and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Minocycline belongs to Anti Bacterial; Pexidartinib belongs to Oncology.
なぜ起こるのか
Additive hepatotoxicity from two drugs that can independently injure the liver.
対処法
Avoid combining where possible and choose a non-hepatotoxic antibiotic. If unavoidable, monitor liver tests frequently and stop at signs of liver injury.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MinocyclineとPexidartinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Minocyclineのその他の相互作用
Pexidartinibのその他の相互作用
よくある質問
Can I take Minocycline with Pexidartinib?
MediHelp rates the interaction as major. Minocycline and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and minocycline can rarely cause hepatotoxicity as well. Using both may add to the risk of liver damage.
How serious is the interaction between Minocycline and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and choose a non-hepatotoxic antibiotic. If unavoidable, monitor liver tests frequently and stop at signs of liver injury.
What other medicines interact with Minocycline?
MediHelp also lists interactions of Minocycline with, for example, Acitretin, Isotretinoin, Cholera vaccine. The full list is on the Minocycline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
