相互作用
Cholera vaccine + Minocycline
重症度: 重大
Cholera vaccine and Minocycline: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
The oral live attenuated cholera vaccine relies on the vaccine strain colonising the gut, and antibiotics active against it can reduce the immune response. Minocycline may therefore make the vaccine less effective.
この相互作用をわかりやすく説明すると
Cholera vaccine and Minocycline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Antibacterial activity against the live attenuated Vibrio cholerae vaccine strain reduces colonisation and immunogenicity.
対処法
Do not give the vaccine to patients who have received systemic antibiotics in the preceding 14 days, and avoid antibiotics for a period after vaccination per labeling. Delay vaccination if needed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Cholera vaccineとMinocyclineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Minocyclineのその他の相互作用
よくある質問
Can I take Cholera vaccine with Minocycline?
MediHelp rates the interaction as major. Cholera vaccine and Minocycline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The oral live attenuated cholera vaccine relies on the vaccine strain colonising the gut, and antibiotics active against it can reduce the immune response. Minocycline may therefore make the vaccine less effective.
How serious is the interaction between Cholera vaccine and Minocycline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine to patients who have received systemic antibiotics in the preceding 14 days, and avoid antibiotics for a period after vaccination per labeling. Delay vaccination if needed.
What other medicines interact with Minocycline?
MediHelp also lists interactions of Minocycline with, for example, Acitretin, Isotretinoin, Methoxyflurane. The full list is on the Minocycline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
