相互作用
Pimozide + Quinine
重症度: 併用禁忌
Pimozide and Quinine: contraindicated interaction.
最終更新日
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概要
Both drugs prolong the QT interval, and quinine also inhibits CYP2D6, potentially raising pimozide levels. The combination markedly raises the risk of torsades de pointes and sudden cardiac death.
この相互作用をわかりやすく説明すると
Pimozide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pimozide belongs to Central Nervous System; Quinine belongs to Anti Parasitic.
なぜ起こるのか
Additive QT prolongation with quinine inhibition of CYP2D6-mediated pimozide metabolism.
対処法
Do not co-administer; use an alternative antimalarial or antipsychotic. If quinine is essential, stop pimozide and monitor the ECG.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、PimozideとQuinineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Quinineのその他の相互作用
Pimozideのその他の相互作用
よくある質問
Can I take Pimozide with Quinine?
MediHelp rates the interaction as contraindicated. Pimozide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and quinine also inhibits CYP2D6, potentially raising pimozide levels. The combination markedly raises the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Pimozide and Quinine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use an alternative antimalarial or antipsychotic. If quinine is essential, stop pimozide and monitor the ECG.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
