相互作用
Arsenic trioxide + Quinine
重症度: 併用禁忌
Arsenic trioxide and Quinine: contraindicated interaction.
最終更新日
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概要
Arsenic trioxide causes marked QT prolongation and torsades de pointes, and quinine adds to this effect. The combination may result in life-threatening arrhythmias.
この相互作用をわかりやすく説明すると
Arsenic trioxide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Quinine belongs to Anti Parasitic.
なぜ起こるのか
Additive pharmacodynamic QT prolongation through cardiac potassium channel effects.
対処法
Avoid the combination; use a non-QT-prolonging antimalarial or cramp treatment during arsenic trioxide therapy. If quinine is essential for severe malaria, monitor ECG continuously and keep electrolytes corrected.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Arsenic trioxideとQuinineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Quinineのその他の相互作用
- Dofetilide + Quinine 併用禁忌
- Dronedarone + Quinine 併用禁忌
- Ibutilide + Quinine 併用禁忌
- Mefloquine + Quinine 併用禁忌
- Nilotinib + Quinine 併用禁忌
- Pimozide + Quinine 併用禁忌
Arsenic trioxideのその他の相互作用
よくある質問
Can I take Arsenic trioxide with Quinine?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide causes marked QT prolongation and torsades de pointes, and quinine adds to this effect. The combination may result in life-threatening arrhythmias.
How serious is the interaction between Arsenic trioxide and Quinine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-QT-prolonging antimalarial or cramp treatment during arsenic trioxide therapy. If quinine is essential for severe malaria, monitor ECG continuously and keep electrolytes corrected.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Quinine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
