相互作用
Mefloquine + Quinine
重症度: 併用禁忌
Mefloquine and Quinine: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Both agents prolong the QT interval and mefloquine can also cause conduction abnormalities and seizures. Given together, or soon after one another, they raise the risk of serious arrhythmias and cardiac arrest.
この相互作用をわかりやすく説明すると
Mefloquine and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mefloquine belongs to Anti Parasitic; Quinine belongs to Anti Parasitic.
なぜ起こるのか
Additive QT prolongation and cardiac conduction effects (pharmacodynamic synergism).
対処法
Avoid concurrent use; do not give mefloquine within about 12 hours after quinine. If quinine is required for severe malaria, use ECG monitoring and avoid mefloquine prophylaxis or treatment.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MefloquineとQuinineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Quinineのその他の相互作用
Mefloquineのその他の相互作用
よくある質問
Can I take Mefloquine with Quinine?
MediHelp rates the interaction as contraindicated. Mefloquine and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong the QT interval and mefloquine can also cause conduction abnormalities and seizures. Given together, or soon after one another, they raise the risk of serious arrhythmias and cardiac arrest.
How serious is the interaction between Mefloquine and Quinine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; do not give mefloquine within about 12 hours after quinine. If quinine is required for severe malaria, use ECG monitoring and avoid mefloquine prophylaxis or treatment.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
