相互作用
Polymyxin b + Rocuronium
重症度: 重大
Polymyxin b and Rocuronium: major interaction.
最終更新日
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概要
Polymyxin B has neuromuscular blocking properties and can intensify and prolong rocuronium paralysis. This can lead to prolonged respiratory muscle weakness or apnea, particularly with renal dysfunction.
この相互作用をわかりやすく説明すると
Polymyxin b and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Polymyxin b belongs to Anti Bacterial; Rocuronium belongs to Musculoskeletal.
なぜ起こるのか
Additive neuromuscular blockade through presynaptic inhibition of acetylcholine release and reduced postsynaptic sensitivity from polymyxin B.
対処法
Avoid concurrent use where an alternative antibiotic is suitable; if needed, reduce rocuronium dose and monitor with train-of-four. Have ventilatory support ready; neostigmine reversal may be incomplete.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Polymyxin bとRocuroniumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Rocuroniumのその他の相互作用
Polymyxin bのその他の相互作用
よくある質問
Can I take Polymyxin b with Rocuronium?
MediHelp rates the interaction as major. Polymyxin b and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Polymyxin B has neuromuscular blocking properties and can intensify and prolong rocuronium paralysis. This can lead to prolonged respiratory muscle weakness or apnea, particularly with renal dysfunction.
How serious is the interaction between Polymyxin b and Rocuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where an alternative antibiotic is suitable; if needed, reduce rocuronium dose and monitor with train-of-four. Have ventilatory support ready; neostigmine reversal may be incomplete.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
