相互作用
Primidone + Roflumilast
重症度: 重大
Primidone and Roflumilast: major interaction.
最終更新日
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概要
Primidone is metabolized to phenobarbital, which induces CYP enzymes and may reduce roflumilast exposure. Clinical benefit of roflumilast may be lost.
この相互作用をわかりやすく説明すると
Primidone and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Primidone belongs to Central Nervous System; Roflumilast belongs to Respiratory.
なぜ起こるのか
Primidone and its phenobarbital metabolite induce CYP3A4 and CYP1A2, increasing roflumilast metabolism.
対処法
Avoid coadministration where feasible and choose a different COPD therapy. If both are needed, monitor clinical response closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、PrimidoneとRoflumilastの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Roflumilastのその他の相互作用
Primidoneのその他の相互作用
よくある質問
Can I take Primidone with Roflumilast?
MediHelp rates the interaction as major. Primidone and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Primidone is metabolized to phenobarbital, which induces CYP enzymes and may reduce roflumilast exposure. Clinical benefit of roflumilast may be lost.
How serious is the interaction between Primidone and Roflumilast?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where feasible and choose a different COPD therapy. If both are needed, monitor clinical response closely.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
