相互作用
Sofosbuvir-velpatasvir-voxilaprevir + St john's wort
重症度: 併用禁忌
Sofosbuvir-velpatasvir-voxilaprevir and St john's wort: contraindicated interaction.
最終更新日
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概要
St John's wort induces P-glycoprotein and CYP enzymes, which can substantially reduce exposure to sofosbuvir, velpatasvir and voxilaprevir. This risks subtherapeutic antiviral levels and treatment failure.
この相互作用をわかりやすく説明すると
Sofosbuvir-velpatasvir-voxilaprevir and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Induction of P-glycoprotein and CYP3A4/CYP2B6/CYP2C8 by hyperforin reduces absorption and increases metabolism of the HCV drugs.
対処法
Avoid the combination; labeling advises against use with St John's wort. Stop the herbal product before starting HCV therapy.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Sofosbuvir-velpatasvir-voxilaprevirとSt john's wortの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Sofosbuvir-velpatasvir-voxilaprevirのその他の相互作用
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
よくある質問
Can I take Sofosbuvir-velpatasvir-voxilaprevir with St john's wort?
MediHelp rates the interaction as contraindicated. Sofosbuvir-velpatasvir-voxilaprevir and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. St John's wort induces P-glycoprotein and CYP enzymes, which can substantially reduce exposure to sofosbuvir, velpatasvir and voxilaprevir. This risks subtherapeutic antiviral levels and treatment failure.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and St john's wort?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; labeling advises against use with St John's wort. Stop the herbal product before starting HCV therapy.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
