相互作用
Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir
重症度: 併用禁忌
Phenytoin and Sofosbuvir-velpatasvir-voxilaprevir: contraindicated interaction.
最終更新日
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概要
Phenytoin induces CYP3A4, CYP2B6 and P-gp and is expected to substantially lower exposure to sofosbuvir, velpatasvir and voxilaprevir. This risks virologic failure. Labeling recommends against use together.
この相互作用をわかりやすく説明すると
Phenytoin and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenytoin belongs to Central Nervous System; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
なぜ起こるのか
Induction of CYP enzymes and P-glycoprotein by phenytoin reduces absorption and increases clearance of the antiviral components.
対処法
Do not coadminister; change to a non-inducing antiepileptic before starting HCV therapy.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、PhenytoinとSofosbuvir-velpatasvir-voxilaprevirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Sofosbuvir-velpatasvir-voxilaprevirのその他の相互作用
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Sofosbuvir-velpatasvir-voxilaprevir + St john's wort 併用禁忌
Phenytoinのその他の相互作用
よくある質問
Can I take Phenytoin with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as contraindicated. Phenytoin and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin induces CYP3A4, CYP2B6 and P-gp and is expected to substantially lower exposure to sofosbuvir, velpatasvir and voxilaprevir. This risks virologic failure. Labeling recommends against use together.
How serious is the interaction between Phenytoin and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; change to a non-inducing antiepileptic before starting HCV therapy.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Primidone. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
