相互作用
Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir
重症度: 併用禁忌
Rifapentine and Sofosbuvir-velpatasvir-voxilaprevir: contraindicated interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Rifapentine is an inducer of CYP enzymes and P-glycoprotein and can markedly lower plasma concentrations of sofosbuvir, velpatasvir and voxilaprevir. This may lead to loss of antiviral activity and failure to achieve sustained virologic response.
この相互作用をわかりやすく説明すると
Rifapentine and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rifapentine belongs to Anti Bacterial; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
なぜ起こるのか
Induction of intestinal and hepatic CYP3A4 and P-glycoprotein by rifapentine increases clearance and reduces absorption of the HCV agents.
対処法
Do not coadminister; rifamycin inducers are not recommended with this regimen. Choose an alternative tuberculosis regimen or delay HCV therapy until rifapentine is completed.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、RifapentineとSofosbuvir-velpatasvir-voxilaprevirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Sofosbuvir-velpatasvir-voxilaprevirのその他の相互作用
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Sofosbuvir-velpatasvir-voxilaprevir + St john's wort 併用禁忌
Rifapentineのその他の相互作用
よくある質問
Can I take Rifapentine with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as contraindicated. Rifapentine and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifapentine is an inducer of CYP enzymes and P-glycoprotein and can markedly lower plasma concentrations of sofosbuvir, velpatasvir and voxilaprevir. This may lead to loss of antiviral activity and failure to achieve sustained virologic response.
How serious is the interaction between Rifapentine and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; rifamycin inducers are not recommended with this regimen. Choose an alternative tuberculosis regimen or delay HCV therapy until rifapentine is completed.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
