Referência de medicamentos
Epoetin
Epoetin is a medicine in the class miscellaneous. It is used for anemia.
- Classe do medicamento: Miscellaneous
- Indicado para: anemia
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Pontos-chave
- Classe do medicamento
- Miscellaneous
- Formas farmacêuticas comuns
- injeção
- Nomes comerciais
- 3
- Países e mercados
- 1
Para que é usado
Como funciona
Epoetin alfa products stimulate erythropoiesis by the same mechanism as endogenous erythropoietin.
Dose habitual em adultos (resumo da bula)
Anemia due to CKD (adults on dialysis or not on dialysis): starting dose 50 to 100 Units/kg 3 times weekly, intravenously or subcutaneously; intravenous route recommended for hemodialysis patients; individualize dosing and use the lowest dose sufficient to reduce RBC transfusions
Gravidez e amamentação
- Gravidez
- Unknown Limited human data; reports in women with kidney disease or anaemia have not reliably shown drug-related harm. In rats, doses near the starting dose caused embryo loss and skeletal and growth effects. Use only if needed; avoid benzyl alcohol (multi-dose) vials.
- Amamentação
- Safe Erythropoietin is a normal part of milk and the drug is poorly absorbed by the infant. LactMed: no special precautions with preservative-free vials. US label: multi-dose vials (benzyl alcohol) are contraindicated; avoid breastfeeding for 2 weeks after such a dose.
Efeitos adversos relatados
- Hypertension
- Arthralgia
- Pyrexia
- Nausea
- Vomiting
- Cough
Advertências de caixa preta
- ESAs increase the risk of death, myocardial infarction, stroke, venous thromboembolism, thrombosis of vascular access and tumor progression or recurrence. CKD: greater risks of death, serious cardiovascular reactions and stroke when targeting hemoglobin above 11 g/dL; no target or dosing strategy avoids these risks; use the lowest dose sufficient to reduce transfusions. Cancer: shortened overall survival and/or increased tumor progression or recurrence in breast, non-small cell lung, head and neck, lymphoid and cervical cancers; use only for anemia from myelosuppressive chemotherapy, not when…
Contraindicações
- Uncontrolled hypertension
- Pure red cell aplasia that begins after treatment with RETACRIT or other erythropoietin protein drugs
- Serious allergic reactions to RETACRIT or other epoetin alfa products
Quem deve ter cuidado
- Increased mortality, MI, stroke and thromboembolism when targeting hemoglobin above 11 g/dL; use caution in coexistent cardiovascular disease and stroke
- Hypertension: control prior to initiating and during treatment
- Seizures: increased risk in CKD; monitor for changes in seizure frequency
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Outros medicamentos desta classe
Perguntas frequentes
What is Epoetin used for?
Epoetin is a medicine in the class miscellaneous. It is used for Anemia.
What side effects have been reported with Epoetin?
Hypertension, Arthralgia, Pyrexia, Nausea, Vomiting, Cough. Serious warning: ESAs increase the risk of death, myocardial infarction, stroke, venous thromboembolism, thrombosis of vascular access and tumor progression or recurrence.
Can Epoetin be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data; reports in women with kidney disease or anaemia have not reliably shown drug-related harm. In rats, doses near the starting dose caused embryo loss and skeletal and growth effects. Use only if needed; avoid benzyl alcohol (multi-dose) vials. Breastfeeding: Safe. Erythropoietin is a normal part of milk and the drug is poorly absorbed by the infant. LactMed: no special precautions with preservative-free vials. US label: multi-dose vials (benzyl alcohol) are contraindicated; avoid breastfeeding for 2 weeks after such a dose.
What does Epoetin interact with?
MediHelp does not list a checked interaction for Epoetin yet. Always tell your pharmacist about every medicine you take.
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