Referência de medicamentos
Interferon beta 1a
Interferon beta 1a is a medicine in the class central nervous system. It is used for multiple sclerosis.
- Classe do medicamento: Central Nervous System
- Indicado para: multiple sclerosis
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Pontos-chave
- Classe do medicamento
- Central Nervous System
- Código ATC
- L03AB07
- Formas farmacêuticas comuns
- injeção
- Concentrações comuns
- 30 mcg/.5 ml, 22 mcg/0.5 ml, 30 mcg
- Interações conhecidas
- 18 (Grave: 9 · Moderada: 8 · Leve: 1)
- Nomes comerciais
- 10
- Países e mercados
- 3
Para que é usado
Como funciona
Recombinant interferon; antiviral, antiproliferative, immunoregulatory protein; alters response to surface antigen and may enhance immune cell activities
Dose habitual em adultos (resumo da bula)
Avonex: 30 mcg IM qWk, starting with 7.5 mcg IM for first week, to reduce flu-like symptoms; increase by 7.5 mcg/week for next 3 weeks until recommended dose of 30 mcg/week
Gravidez e amamentação
- Gravidez
- Safe Registry and cohort data (over 1000 pregnancies) show no rise in major birth defects; miscarriage data are inconsistent, and high doses caused miscarriage in monkeys. EU label: may be considered in pregnancy if clinically needed. Plan treatment with the MS specialist.
- Amamentação
- Safe Milk levels are negligible and it is poorly absorbed by mouth. EU label: can be used while breastfeeding. LactMed: many breastfed infants without adverse effects; a preferred MS treatment while nursing, and feeds can resume right after an injection.
Efeitos adversos relatados
- Headache
- Nausea
- Injection site reactions
- Flu-like syndrome
- Muscle ache
- URT infection
Quem deve ter cuidado
- Thyroid function should be monitored periodically If patients have or develop symptoms of thyroid dysfunction (hypo- or hyperthyroidism),
- Seizures have been temporally associated with use of beta interferons in clinical trials and postmarketing safety surveillance
- Cases of thrombotic microangiopathy (TMA), including thrombotic thrombocytopenic purpura and hemolytic uremic syndrome, some fatal, have been reported
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (18)
- Deferiprone + Interferon beta 1a Major
- Etrasimod + Interferon beta 1a Major
- Hydroxyurea + Interferon beta 1a Major
- Idecabtagene vicleucel + Interferon beta 1a Major
- Interferon beta 1a + Lisocabtagene maraleucel Major
- Interferon beta 1a + Pexidartinib Major
- Interferon beta 1a + Pretomanid Major
- Interferon beta 1a + Ropeginterferon alfa 2b Major
- Interferon beta 1a + Tisagenlecleucel Major
- Acalabrutinib + Interferon beta 1a Moderate
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- Patient counselling points
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Perguntas frequentes
What is Interferon beta 1a used for?
Interferon beta 1a is a medicine in the class central nervous system. It is used for Multiple sclerosis.
What side effects have been reported with Interferon beta 1a?
Headache, Nausea, Injection site reactions, Flu-like syndrome, Muscle ache, URT infection.
Can Interferon beta 1a be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Registry and cohort data (over 1000 pregnancies) show no rise in major birth defects; miscarriage data are inconsistent, and high doses caused miscarriage in monkeys. EU label: may be considered in pregnancy if clinically needed. Plan treatment with the MS specialist. Breastfeeding: Safe. Milk levels are negligible and it is poorly absorbed by mouth. EU label: can be used while breastfeeding. LactMed: many breastfed infants without adverse effects; a preferred MS treatment while nursing, and feeds can resume right after an injection.
What does Interferon beta 1a interact with?
MediHelp lists 18 known interactions for Interferon beta 1a. Major: 9 · Moderate: 8 · Minor: 1. The most serious include Deferiprone, Etrasimod, Hydroxyurea.
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