Referência de medicamentos
Ivacaftor
Ivacaftor is a medicine in the class miscellaneous. It is used for cystic fibrosis.
- Classe do medicamento: Miscellaneous
- Indicado para: cystic fibrosis
Última atualização Fontes: US FDA label
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Pontos-chave
- Classe do medicamento
- Miscellaneous
- Código ATC
- R07AX02
- Formas farmacêuticas comuns
- comprimido
- Concentrações comuns
- 150 mg
- Interações conhecidas
- 119 (Contraindicada: 1 · Grave: 10 · Moderada: 51 · Leve: 57)
- Nomes comerciais
- 3
- Países e mercados
- 3
Para que é usado
Como funciona
Ivacaftor is a CFTR potentiator that increases chloride transport by increasing the channel open probability (gating) of CFTR protein at the cell surface.
Dose habitual em adultos (resumo da bula)
Cystic fibrosis (adults and patients aged 6 years and older): 150 mg orally every 12 hours (300 mg total daily dose) with fat-containing food
Gravidez e amamentação
- Gravidez
- Unknown Limited human data (under 300 pregnancies); no harm in rats or rabbits at 5 to 11 times human exposure. EU label: as a precaution, preferable to avoid. Stopping may worsen cystic fibrosis, and CF teams often continue it, so decide with the CF specialist.
- Amamentação
- Safe Low milk levels and very low infant blood levels; no infant harm reported, and expert groups consider it probably safe. EU label: weigh benefits. LactMed: check the infant's liver tests and eyes (cataracts) periodically, and test for CF, as it can mask it.
Efeitos adversos relatados
- Headache
- Upper respiratory tract infection
- Nasal congestion
- Nausea
- Rash
- Oropharyngeal pain
Quem deve ter cuidado
- Elevated transaminases: assess ALT/AST before starting, every 3 months in first year, then annually; interrupt dosing if ALT or AST greater than 5 times ULN.
- Hypersensitivity reactions including anaphylaxis reported postmarketing; discontinue and treat if serious signs develop.
- Intracranial hypertension reported with similar active ingredients; interrupt and refer if unusual headache or visual disturbances occur.
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Principais interações (119)
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
- Ivacaftor + Oxcarbazepine Major
- Ivacaftor + Phenobarbitone Major
- Ivacaftor + Phenytoin Major
- Ivacaftor + Rifabutin Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Perguntas frequentes
What is Ivacaftor used for?
Ivacaftor is a medicine in the class miscellaneous. It is used for Cystic fibrosis.
What side effects have been reported with Ivacaftor?
Headache, Upper respiratory tract infection, Nasal congestion, Nausea, Rash, Oropharyngeal pain.
Can Ivacaftor be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data (under 300 pregnancies); no harm in rats or rabbits at 5 to 11 times human exposure. EU label: as a precaution, preferable to avoid. Stopping may worsen cystic fibrosis, and CF teams often continue it, so decide with the CF specialist. Breastfeeding: Safe. Low milk levels and very low infant blood levels; no infant harm reported, and expert groups consider it probably safe. EU label: weigh benefits. LactMed: check the infant's liver tests and eyes (cataracts) periodically, and test for CF, as it can mask it.
What does Ivacaftor interact with?
MediHelp lists 119 known interactions for Ivacaftor. Contraindicated: 1 · Major: 10 · Moderate: 51 · Minor: 57. The most serious include Ensitrelvir, Apalutamide, Carbamazepine.
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