Interações medicamentosas
Ensitrelvir + Ivacaftor
Gravidade: Contraindicada
Ensitrelvir and Ivacaftor: contraindicated interaction.
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Resumo
The inducing component of lumacaftor/ivacaftor is a strong CYP3A inducer, so combination products lower ensitrelvir levels. Ivacaftor alone is a weak CYP3A substrate with little inducing effect, so the concern applies mainly to lumacaftor-containing regimens. Reduced ensitrelvir exposure may compromise antiviral response.
O que esta interação significa em palavras simples
Ensitrelvir and Ivacaftor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ensitrelvir belongs to Anti Virals; Ivacaftor belongs to Miscellaneous.
Por que acontece
Lumacaftor (co-formulated with ivacaftor) induces CYP3A, increasing ensitrelvir clearance.
O que fazer
Avoid ensitrelvir in patients taking lumacaftor/ivacaftor and choose an alternative antiviral. Ivacaftor monotherapy does not carry this induction concern but check the exact product.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Ensitrelvir
- Apalutamide + Ensitrelvir Contraindicada
- Carbamazepine + Ensitrelvir Contraindicada
- Colchicine + Ensitrelvir Contraindicada
- Ensitrelvir + Enzalutamide Contraindicada
- Ensitrelvir + Eplerenone Contraindicada
- Ensitrelvir + Finerenone Contraindicada
Outras interações de Ivacaftor
- Apalutamide + Ivacaftor Grave
- Carbamazepine + Ivacaftor Grave
- Clarithromycin + Ivacaftor Grave
- Efavirenz + Ivacaftor Grave
- Enzalutamide + Ivacaftor Grave
- Ivacaftor + Oxcarbazepine Grave
Perguntas frequentes
Can I take Ensitrelvir with Ivacaftor?
MediHelp rates the interaction as contraindicated. Ensitrelvir and Ivacaftor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The inducing component of lumacaftor/ivacaftor is a strong CYP3A inducer, so combination products lower ensitrelvir levels. Ivacaftor alone is a weak CYP3A substrate with little inducing effect, so the concern applies mainly to lumacaftor-containing regimens. Reduced ensitrelvir exposure may compromise antiviral response.
How serious is the interaction between Ensitrelvir and Ivacaftor?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ensitrelvir in patients taking lumacaftor/ivacaftor and choose an alternative antiviral. Ivacaftor monotherapy does not carry this induction concern but check the exact product.
What other medicines interact with Ensitrelvir?
MediHelp also lists interactions of Ensitrelvir with, for example, Apalutamide, Carbamazepine, Colchicine. The full list is on the Ensitrelvir page.
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