Interações medicamentosas
Ivacaftor + Phenytoin
Gravidade: Grave
Ivacaftor and Phenytoin: major interaction.
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Resumo
Strong CYP3A4 inducers markedly reduce ivacaftor exposure, which may lead to loss of CFTR potentiation and loss of clinical benefit. Phenytoin is expected to behave similarly.
O que esta interação significa em palavras simples
Ivacaftor and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivacaftor belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
Por que acontece
Phenytoin induces CYP3A4, greatly increasing ivacaftor metabolism.
O que fazer
Avoid coadministration and choose a non-inducing antiseizure drug. Monitor lung function if it cannot be avoided.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicada
- Bictegravir + Phenytoin Contraindicada
- Cabotegravir + Phenytoin Contraindicada
- Doravirine + Phenytoin Contraindicada
- Elbasvir / grazoprevir + Phenytoin Contraindicada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicada
Outras interações de Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicada
- Apalutamide + Ivacaftor Grave
- Carbamazepine + Ivacaftor Grave
- Clarithromycin + Ivacaftor Grave
- Efavirenz + Ivacaftor Grave
- Enzalutamide + Ivacaftor Grave
Perguntas frequentes
Can I take Ivacaftor with Phenytoin?
MediHelp rates the interaction as major. Ivacaftor and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inducers markedly reduce ivacaftor exposure, which may lead to loss of CFTR potentiation and loss of clinical benefit. Phenytoin is expected to behave similarly.
How serious is the interaction between Ivacaftor and Phenytoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and choose a non-inducing antiseizure drug. Monitor lung function if it cannot be avoided.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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