Interações medicamentosas
Abrocitinib + Ticagrelor
Gravidade: Grave
Abrocitinib and Ticagrelor: major interaction.
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Resumo
Abrocitinib reduces platelet counts, mainly in the early weeks of treatment, and its labeling advises against antiplatelet drugs other than low-dose aspirin during the first 3 months. Adding ticagrelor, a potent P2Y12 inhibitor, to thrombocytopenia increases the risk of significant bleeding.
O que esta interação significa em palavras simples
Abrocitinib and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Abrocitinib belongs to Miscellaneous; Ticagrelor belongs to Cardiovascular.
Por que acontece
Additive bleeding risk from ticagrelor platelet inhibition combined with abrocitinib-associated reduction in platelet count.
O que fazer
Avoid starting abrocitinib in patients who need ticagrelor during the first 3 months, or choose an alternative therapy. If unavoidable, monitor platelet counts and bleeding signs closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Ticagrelor
- Itraconazole + Ticagrelor Contraindicada
- Ketoconazole + Ticagrelor Contraindicada
- Levoketoconazole + Ticagrelor Contraindicada
- Abciximab + Ticagrelor Grave
- Acalabrutinib + Ticagrelor Grave
- Acetylsalicylic acid + Ticagrelor Grave
Outras interações de Abrocitinib
- Abrocitinib + Upadacitinib Contraindicada
- Abciximab + Abrocitinib Grave
- Abrocitinib + Anagrelide Grave
- Abrocitinib + Cilostazol Grave
- Abrocitinib + Clopidogrel Grave
- Abrocitinib + Eptifibatide Grave
Perguntas frequentes
Can I take Abrocitinib with Ticagrelor?
MediHelp rates the interaction as major. Abrocitinib and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Abrocitinib reduces platelet counts, mainly in the early weeks of treatment, and its labeling advises against antiplatelet drugs other than low-dose aspirin during the first 3 months. Adding ticagrelor, a potent P2Y12 inhibitor, to thrombocytopenia increases the risk of significant bleeding.
How serious is the interaction between Abrocitinib and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting abrocitinib in patients who need ticagrelor during the first 3 months, or choose an alternative therapy. If unavoidable, monitor platelet counts and bleeding signs closely.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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