Interações medicamentosas
Acarbose + Clozapine
Gravidade: Moderada
Acarbose and Clozapine: moderate interaction.
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Resumo
Clozapine frequently causes hyperglycemia, insulin resistance and new-onset diabetes, which can oppose the glucose-lowering effect of acarbose. Glycemic control may deteriorate or require adjustment of diabetes therapy.
O que esta interação significa em palavras simples
Acarbose and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acarbose belongs to Endocrine; Clozapine belongs to Central Nervous System.
Por que acontece
Pharmacodynamic antagonism, as clozapine impairs glucose tolerance and insulin sensitivity.
O que fazer
Monitor fasting glucose and HbA1c regularly after starting or changing clozapine. Adjust the antidiabetic regimen as needed.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Clozapine
- Clozapine + Deferiprone Contraindicada
- Clozapine + Irinotecan Contraindicada
- Clozapine + Pimozide Contraindicada
- Clozapine + Thioridazine Contraindicada
- Acalabrutinib + Clozapine Grave
- Adagrasib + Clozapine Grave
Outras interações de Acarbose
- Acarbose + Pramlintide Grave
- Acarbose + Asenapine Moderada
- Acarbose + Bitter melon Moderada
- Acarbose + Ciprofloxacin Moderada
- Acarbose + Cortisone Moderada
- Acarbose + Deflazacort Moderada
Perguntas frequentes
Can I take Acarbose with Clozapine?
MediHelp rates the interaction as moderate. Acarbose and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine frequently causes hyperglycemia, insulin resistance and new-onset diabetes, which can oppose the glucose-lowering effect of acarbose. Glycemic control may deteriorate or require adjustment of diabetes therapy.
How serious is the interaction between Acarbose and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c regularly after starting or changing clozapine. Adjust the antidiabetic regimen as needed.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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