Interações medicamentosas
Activated charcoal + Methotrexate
Gravidade: Moderada
Activated charcoal and Methotrexate: moderate interaction.
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Resumo
Activated charcoal binds methotrexate in the gut and can interrupt its enterohepatic recirculation, lowering its levels. This reduces the effect of therapeutic doses but is used deliberately in overdose.
O que esta interação significa em palavras simples
Activated charcoal and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Activated charcoal belongs to Gastrointestinal Tract; Methotrexate belongs to Oncology.
Por que acontece
Adsorption of methotrexate in the gastrointestinal tract reduces absorption and enterohepatic reabsorption.
O que fazer
Separate charcoal from oral methotrexate doses unless it is being given for overdose. In overdose, consider repeated charcoal alongside leucovorin and supportive care.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Methotrexate
- Acitretin + Methotrexate Contraindicada
- Adenovirus types 4 and 7 live + Methotrexate Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicada
- Ketorolac + Methotrexate Contraindicada
- Measles mumps and rubella vaccine live + Methotrexate Contraindicada
- Measles mumps and rubella vaccine + Methotrexate Contraindicada
Outras interações de Activated charcoal
- Activated charcoal + Mycophenolic acid Grave
- Activated charcoal + Amlodipine Moderada
- Activated charcoal + Citalopram Moderada
- Activated charcoal + Digoxin Moderada
- Activated charcoal + Leflunomide Moderada
- Activated charcoal + Theophylline Moderada
Perguntas frequentes
Can I take Activated charcoal with Methotrexate?
MediHelp rates the interaction as moderate. Activated charcoal and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Activated charcoal binds methotrexate in the gut and can interrupt its enterohepatic recirculation, lowering its levels. This reduces the effect of therapeutic doses but is used deliberately in overdose.
How serious is the interaction between Activated charcoal and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate charcoal from oral methotrexate doses unless it is being given for overdose. In overdose, consider repeated charcoal alongside leucovorin and supportive care.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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