Interações medicamentosas
Measles mumps and rubella vaccine live + Methotrexate
Gravidade: Contraindicada
Measles mumps and rubella vaccine live and Methotrexate: contraindicated interaction.
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Resumo
Live MMR vaccine may cause disseminated vaccine-virus infection in patients receiving methotrexate, and the immune response may be impaired. Low-dose methotrexate is sometimes judged acceptable in individual cases, but higher doses clearly raise risk.
O que esta interação significa em palavras simples
Measles mumps and rubella vaccine live and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Methotrexate suppresses lymphocyte proliferation, allowing replication of live attenuated viruses.
O que fazer
Avoid live MMR during methotrexate therapy; vaccinate at least 4 weeks before starting if possible. Any decision to vaccinate on low-dose methotrexate should be specialist-led.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Methotrexate
- Acitretin + Methotrexate Contraindicada
- Adenovirus types 4 and 7 live + Methotrexate Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicada
- Ketorolac + Methotrexate Contraindicada
- Measles mumps and rubella vaccine + Methotrexate Contraindicada
- Measles mumps rubella and varicella vaccine live + Methotrexate Contraindicada
Perguntas frequentes
Can I take Measles mumps and rubella vaccine live with Methotrexate?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine live and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live MMR vaccine may cause disseminated vaccine-virus infection in patients receiving methotrexate, and the immune response may be impaired. Low-dose methotrexate is sometimes judged acceptable in individual cases, but higher doses clearly raise risk.
How serious is the interaction between Measles mumps and rubella vaccine live and Methotrexate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live MMR during methotrexate therapy; vaccinate at least 4 weeks before starting if possible. Any decision to vaccinate on low-dose methotrexate should be specialist-led.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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