Interações medicamentosas
Adenovirus types 4 and 7 live + Certolizumab pegol
Gravidade: Contraindicada
Adenovirus types 4 and 7 live and Certolizumab pegol: contraindicated interaction.
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Resumo
The oral adenovirus type 4 and 7 vaccine contains live virus. Under TNF blockade with certolizumab, replication may be poorly controlled, risking vaccine-related infection and a reduced immune response.
O que esta interação significa em palavras simples
Adenovirus types 4 and 7 live and Certolizumab pegol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
TNF inhibition impairs immune control of live attenuated virus, raising infection risk and reducing vaccine response.
O que fazer
Avoid this live vaccine during certolizumab therapy. Vaccinate before starting treatment if indicated, allowing at least 4 weeks.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
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Outras interações de Certolizumab pegol
- Bcg intravesical live + Certolizumab pegol Contraindicada
- Bcg vaccine live + Certolizumab pegol Contraindicada
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicada
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicada
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicada
- Certolizumab pegol + Measles mumps rubella and varicella vaccine live Contraindicada
Perguntas frequentes
Can I take Adenovirus types 4 and 7 live with Certolizumab pegol?
MediHelp rates the interaction as contraindicated. Adenovirus types 4 and 7 live and Certolizumab pegol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The oral adenovirus type 4 and 7 vaccine contains live virus. Under TNF blockade with certolizumab, replication may be poorly controlled, risking vaccine-related infection and a reduced immune response.
How serious is the interaction between Adenovirus types 4 and 7 live and Certolizumab pegol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid this live vaccine during certolizumab therapy. Vaccinate before starting treatment if indicated, allowing at least 4 weeks.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Bcg intravesical live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Certolizumab pegol page.
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