Interações medicamentosas
Adenovirus types 4 and 7 live + Cyclophosphamide
Gravidade: Grave
Adenovirus types 4 and 7 live and Cyclophosphamide: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Cyclophosphamide suppresses immune function, which can blunt the response to the vaccine. Because the vaccine contains live virus, an immunosuppressed patient may develop disseminated vaccine-strain infection.
O que esta interação significa em palavras simples
Adenovirus types 4 and 7 live and Cyclophosphamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Cytotoxic immunosuppression impairs vaccine immune response and permits replication of the live attenuated virus.
O que fazer
Avoid the live vaccine during cyclophosphamide therapy and for at least 3 months after it ends. Choose a non-live alternative where one is available.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cyclophosphamide
Perguntas frequentes
Can I take Adenovirus types 4 and 7 live with Cyclophosphamide?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Cyclophosphamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclophosphamide suppresses immune function, which can blunt the response to the vaccine. Because the vaccine contains live virus, an immunosuppressed patient may develop disseminated vaccine-strain infection.
How serious is the interaction between Adenovirus types 4 and 7 live and Cyclophosphamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live vaccine during cyclophosphamide therapy and for at least 3 months after it ends. Choose a non-live alternative where one is available.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Belatacept, Bendamustine, Busulfan. The full list is on the Cyclophosphamide page.
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