Interações medicamentosas
Cyclophosphamide + Dengue vaccine
Gravidade: Grave
Cyclophosphamide and Dengue vaccine: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Cyclophosphamide suppresses immune function and may blunt the antibody response to the dengue vaccine, leaving the patient inadequately protected. The dengue vaccine is live attenuated, so vaccination during significant immunosuppression also carries a risk of vaccine-related infection.
O que esta interação significa em palavras simples
Cyclophosphamide and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Cytotoxic immunosuppression reduces vaccine immune response and impairs control of live attenuated virus replication.
O que fazer
Avoid giving the live dengue vaccine during cyclophosphamide therapy; vaccinate at least several weeks before starting treatment or after immune recovery, as advised by specialist guidance.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cyclophosphamide
Perguntas frequentes
Can I take Cyclophosphamide with Dengue vaccine?
MediHelp rates the interaction as major. Cyclophosphamide and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclophosphamide suppresses immune function and may blunt the antibody response to the dengue vaccine, leaving the patient inadequately protected. The dengue vaccine is live attenuated, so vaccination during significant immunosuppression also carries a risk of vaccine-related infection.
How serious is the interaction between Cyclophosphamide and Dengue vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the live dengue vaccine during cyclophosphamide therapy; vaccinate at least several weeks before starting treatment or after immune recovery, as advised by specialist guidance.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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