Interações medicamentosas
Busulfan + Cyclophosphamide
Gravidade: Grave
Busulfan and Cyclophosphamide: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Both agents are myelosuppressive alkylators, and together they markedly increase marrow toxicity. Busulfan given shortly before cyclophosphamide may also alter cyclophosphamide metabolism and increase hepatic toxicity such as veno-occlusive disease.
O que esta interação significa em palavras simples
Busulfan and Cyclophosphamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Busulfan belongs to Oncology; Cyclophosphamide belongs to Oncology.
Por que acontece
Additive myelosuppression, with busulfan depleting glutathione and competing for hepatic metabolism of cyclophosphamide.
O que fazer
Use only in planned regimens with established sequencing and doses, and monitor blood counts and liver function closely. Allow an interval between busulfan and cyclophosphamide as specified in the protocol.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cyclophosphamide
Outras interações de Busulfan
- Busulfan + Carboplatin Grave
- Busulfan + Chlorambucil Grave
- Busulfan + Fingolimod Grave
- Busulfan + Hydroxyurea Grave
- Busulfan + Ifosfamide Grave
- Busulfan + Itraconazole Grave
Perguntas frequentes
Can I take Busulfan with Cyclophosphamide?
MediHelp rates the interaction as major. Busulfan and Cyclophosphamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are myelosuppressive alkylators, and together they markedly increase marrow toxicity. Busulfan given shortly before cyclophosphamide may also alter cyclophosphamide metabolism and increase hepatic toxicity such as veno-occlusive disease.
How serious is the interaction between Busulfan and Cyclophosphamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only in planned regimens with established sequencing and doses, and monitor blood counts and liver function closely. Allow an interval between busulfan and cyclophosphamide as specified in the protocol.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
Monografias completas, posologia e verificador de interações no app MediHelp
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