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Interações medicamentosas

Adenovirus types 4 and 7 live + Etoposide

Gravidade: Contraindicada

Adenovirus types 4 and 7 live and Etoposide: contraindicated interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Etoposide causes immunosuppression, so a live adenovirus vaccine may cause uncontrolled vaccine-virus replication and disease. The vaccine response may also be inadequate.

O que esta interação significa em palavras simples

Adenovirus types 4 and 7 live and Etoposide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Nível de evidência: Moderate

Por que acontece

Chemotherapy-induced immunosuppression impairs control of live attenuated virus and reduces vaccine immunogenicity.

O que fazer

Do not give the live vaccine during etoposide therapy; wait at least 3 months after chemotherapy ends and until immune recovery.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

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Perguntas frequentes

Can I take Adenovirus types 4 and 7 live with Etoposide?

MediHelp rates the interaction as contraindicated. Adenovirus types 4 and 7 live and Etoposide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Etoposide causes immunosuppression, so a live adenovirus vaccine may cause uncontrolled vaccine-virus replication and disease. The vaccine response may also be inadequate.

How serious is the interaction between Adenovirus types 4 and 7 live and Etoposide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the live vaccine during etoposide therapy; wait at least 3 months after chemotherapy ends and until immune recovery.

What other medicines interact with Etoposide?

MediHelp also lists interactions of Etoposide with, for example, Pentostatin, Cyclosporine, Cyclosporin. The full list is on the Etoposide page.

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