Interações medicamentosas
Cyclosporine + Etoposide
Gravidade: Grave
Cyclosporine and Etoposide: major interaction.
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Resumo
Cyclosporine inhibits CYP3A4 and P-glycoprotein and can markedly raise etoposide exposure. This may cause more severe myelosuppression and mucositis, and cyclosporine's own immunosuppression adds to the risk of infection.
O que esta interação significa em palavras simples
Cyclosporine and Etoposide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Inhibition of P-gp efflux and CYP3A4 metabolism of etoposide by cyclosporine.
O que fazer
Reduce the etoposide dose when given with cyclosporine and monitor blood counts closely. Watch for infection and mucositis.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicada
- Etoposide + Pentostatin Contraindicada
- Cyclosporin + Etoposide Grave
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Grave
- Etoposide + Fingolimod Grave
- Etoposide + Fosphenytoin Grave
Perguntas frequentes
Can I take Cyclosporine with Etoposide?
MediHelp rates the interaction as major. Cyclosporine and Etoposide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits CYP3A4 and P-glycoprotein and can markedly raise etoposide exposure. This may cause more severe myelosuppression and mucositis, and cyclosporine's own immunosuppression adds to the risk of infection.
How serious is the interaction between Cyclosporine and Etoposide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the etoposide dose when given with cyclosporine and monitor blood counts closely. Watch for infection and mucositis.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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