Interações medicamentosas
Alemtuzumab + Denosumab
Gravidade: Moderada
Alemtuzumab and Denosumab: moderate interaction.
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Resumo
Alemtuzumab causes profound, prolonged lymphocyte depletion, and denosumab has been linked to serious infections. The combination may increase the risk of serious or opportunistic infection.
O que esta interação significa em palavras simples
Alemtuzumab and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alemtuzumab belongs to Miscellaneous; Denosumab belongs to Oncology.
Por que acontece
Additive immunosuppression from profound lymphocyte depletion by alemtuzumab and RANKL inhibition by denosumab.
O que fazer
Monitor closely for infection during and after alemtuzumab, and consider whether denosumab can be timed or deferred. Start prompt evaluation of any fever or infectious symptoms.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Denosumab
- Abatacept + Denosumab Moderada
- Adalimumab + Denosumab Moderada
- Alefacept + Denosumab Moderada
- Anakinra + Denosumab Moderada
- Azacitidine + Denosumab Moderada
- Azathioprine + Denosumab Moderada
Outras interações de Alemtuzumab
- Alemtuzumab + Fingolimod Grave
- Alemtuzumab + Ifosfamide Grave
- Alemtuzumab + Lomustine Grave
- Alemtuzumab + Ozanimod Grave
- Alemtuzumab + Siponimod Grave
- Alemtuzumab + Upadacitinib Grave
Perguntas frequentes
Can I take Alemtuzumab with Denosumab?
MediHelp rates the interaction as moderate. Alemtuzumab and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alemtuzumab causes profound, prolonged lymphocyte depletion, and denosumab has been linked to serious infections. The combination may increase the risk of serious or opportunistic infection.
How serious is the interaction between Alemtuzumab and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for infection during and after alemtuzumab, and consider whether denosumab can be timed or deferred. Start prompt evaluation of any fever or infectious symptoms.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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