Interações medicamentosas
Azathioprine + Denosumab
Gravidade: Moderada
Azathioprine and Denosumab: moderate interaction.
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Resumo
Denosumab has been associated with serious infections, including skin and urinary tract infections, and the risk may be higher in patients on immunosuppressants. Azathioprine adds to this by suppressing lymphocyte proliferation, so the combination can increase infection susceptibility.
O que esta interação significa em palavras simples
Azathioprine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azathioprine belongs to Gastrointestinal Tract; Denosumab belongs to Oncology.
Por que acontece
Additive pharmacodynamic effects on immune function; denosumab inhibits RANKL signalling while azathioprine impairs purine synthesis in lymphocytes.
O que fazer
Counsel the patient to report fever or signs of infection promptly and treat infections early. Monitor for infection and review the need for continued immunosuppression if serious infections occur.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicada
- Azathioprine + Bcg vaccine live Contraindicada
- Azathioprine + Febuxostat Contraindicada
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicada
- Azathioprine + Measles mumps and rubella vaccine Contraindicada
- Azathioprine + Measles mumps and rubella vaccine live Contraindicada
Outras interações de Denosumab
- Abatacept + Denosumab Moderada
- Adalimumab + Denosumab Moderada
- Alefacept + Denosumab Moderada
- Alemtuzumab + Denosumab Moderada
- Anakinra + Denosumab Moderada
- Azacitidine + Denosumab Moderada
Perguntas frequentes
Can I take Azathioprine with Denosumab?
MediHelp rates the interaction as moderate. Azathioprine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab has been associated with serious infections, including skin and urinary tract infections, and the risk may be higher in patients on immunosuppressants. Azathioprine adds to this by suppressing lymphocyte proliferation, so the combination can increase infection susceptibility.
How serious is the interaction between Azathioprine and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report fever or signs of infection promptly and treat infections early. Monitor for infection and review the need for continued immunosuppression if serious infections occur.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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