Interações medicamentosas
Anakinra + Denosumab
Gravidade: Moderada
Anakinra and Denosumab: moderate interaction.
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Resumo
Anakinra blocks IL-1 and carries a risk of serious infection, and denosumab labeling advises caution with concomitant immunosuppressants. Combined use may further increase infection risk.
O que esta interação significa em palavras simples
Anakinra and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anakinra belongs to Musculoskeletal; Denosumab belongs to Oncology.
Por que acontece
Additive infection risk from IL-1 receptor blockade and RANKL inhibition; no pharmacokinetic mechanism.
O que fazer
Monitor for signs of infection and treat early. Interrupt therapy if a serious infection develops.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Anakinra
- Anakinra + Bcg vaccine live Contraindicada
- Anakinra + Measles mumps and rubella vaccine Contraindicada
- Anakinra + Measles mumps and rubella vaccine live Contraindicada
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicada
- Anakinra + Measles vaccine Contraindicada
- Abatacept + Anakinra Grave
Outras interações de Denosumab
- Abatacept + Denosumab Moderada
- Adalimumab + Denosumab Moderada
- Alefacept + Denosumab Moderada
- Alemtuzumab + Denosumab Moderada
- Azacitidine + Denosumab Moderada
- Azathioprine + Denosumab Moderada
Perguntas frequentes
Can I take Anakinra with Denosumab?
MediHelp rates the interaction as moderate. Anakinra and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anakinra blocks IL-1 and carries a risk of serious infection, and denosumab labeling advises caution with concomitant immunosuppressants. Combined use may further increase infection risk.
How serious is the interaction between Anakinra and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and treat early. Interrupt therapy if a serious infection develops.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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