Interações medicamentosas
Alfentanil + Diazepam
Gravidade: Grave
Alfentanil and Diazepam: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Combining a benzodiazepine with an opioid such as alfentanil increases the risk of profound sedation, respiratory depression, hypotension and death. Benzodiazepines are often combined with alfentanil for anesthesia, which requires dose reduction and monitoring.
O que esta interação significa em palavras simples
Alfentanil and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS and respiratory depression via GABA-A and opioid receptor activity.
O que fazer
Reduce doses and titrate each drug carefully, with continuous monitoring of oxygenation and ventilation. Ensure airway equipment and naloxone or flumazenil are available.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Diazepam
Perguntas frequentes
Can I take Alfentanil with Diazepam?
MediHelp rates the interaction as major. Alfentanil and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a benzodiazepine with an opioid such as alfentanil increases the risk of profound sedation, respiratory depression, hypotension and death. Benzodiazepines are often combined with alfentanil for anesthesia, which requires dose reduction and monitoring.
How serious is the interaction between Alfentanil and Diazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce doses and titrate each drug carefully, with continuous monitoring of oxygenation and ventilation. Ensure airway equipment and naloxone or flumazenil are available.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alprazolam, Amobarbital. The full list is on the Diazepam page.
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