Interações medicamentosas
Belladonna and opium + Diazepam
Gravidade: Grave
Belladonna and opium and Diazepam: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Belladonna and opium suppositories contain an opioid, so combination with diazepam increases the risk of profound sedation, respiratory depression, coma and death. Opioid labeling carries a boxed warning for concomitant benzodiazepine use.
O que esta interação significa em palavras simples
Belladonna and opium and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS and respiratory depression via opioid and GABA-A receptor activity.
O que fazer
Avoid combining where possible, or use the lowest doses for the shortest time with close monitoring of sedation and breathing. Counsel patients and caregivers about warning signs.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Diazepam
Perguntas frequentes
Can I take Belladonna and opium with Diazepam?
MediHelp rates the interaction as major. Belladonna and opium and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Belladonna and opium suppositories contain an opioid, so combination with diazepam increases the risk of profound sedation, respiratory depression, coma and death. Opioid labeling carries a boxed warning for concomitant benzodiazepine use.
How serious is the interaction between Belladonna and opium and Diazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or use the lowest doses for the shortest time with close monitoring of sedation and breathing. Counsel patients and caregivers about warning signs.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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