Interações medicamentosas
Calcium / magnesium / potassium / sodium oxybates + Diazepam
Gravidade: Contraindicada
Calcium / magnesium / potassium / sodium oxybates and Diazepam: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Oxybates are potent CNS depressants, and combined with a benzodiazepine they can cause profound sedation, respiratory depression, coma and death. Labeling advises against combining them with sedative hypnotics.
O que esta interação significa em palavras simples
Calcium / magnesium / potassium / sodium oxybates and Diazepam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Additive CNS and respiratory depression via GABA-A potentiation and GABA-B/GHB receptor activation.
O que fazer
Avoid concomitant use; if a benzodiazepine is unavoidable, consider an alternative to oxybate or stopping one agent. Monitor consciousness and breathing closely if exposure cannot be avoided.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Calcium / magnesium / potassium / sodium oxybates e Diazepam, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Diazepam
Perguntas frequentes
Can I take Calcium / magnesium / potassium / sodium oxybates with Diazepam?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Diazepam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxybates are potent CNS depressants, and combined with a benzodiazepine they can cause profound sedation, respiratory depression, coma and death. Labeling advises against combining them with sedative hypnotics.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Diazepam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; if a benzodiazepine is unavoidable, consider an alternative to oxybate or stopping one agent. Monitor consciousness and breathing closely if exposure cannot be avoided.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Diazepam page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
