Interações medicamentosas
Alogliptin-metformin + Mecasermin
Gravidade: Moderada
Alogliptin-metformin and Mecasermin: moderate interaction.
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Resumo
Mecasermin is recombinant IGF-1 and can cause significant hypoglycemia. Added to antidiabetic drugs, it may increase the risk of low blood glucose, although metformin and alogliptin carry little hypoglycemia risk alone.
O que esta interação significa em palavras simples
Alogliptin-metformin and Mecasermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-metformin belongs to Endocrine; Mecasermin belongs to Endocrine.
Por que acontece
IGF-1 has insulin-like glucose-lowering activity that adds to the effects of antidiabetic drugs.
O que fazer
Give mecasermin with or shortly after a meal and monitor blood glucose frequently. Educate the patient about hypoglycemia symptoms and adjust antidiabetic doses as required.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Alogliptin-metformin
Outras interações de Mecasermin
Perguntas frequentes
Can I take Alogliptin-metformin with Mecasermin?
MediHelp rates the interaction as moderate. Alogliptin-metformin and Mecasermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mecasermin is recombinant IGF-1 and can cause significant hypoglycemia. Added to antidiabetic drugs, it may increase the risk of low blood glucose, although metformin and alogliptin carry little hypoglycemia risk alone.
How serious is the interaction between Alogliptin-metformin and Mecasermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give mecasermin with or shortly after a meal and monitor blood glucose frequently. Educate the patient about hypoglycemia symptoms and adjust antidiabetic doses as required.
What other medicines interact with Alogliptin-metformin?
MediHelp also lists interactions of Alogliptin-metformin with, for example, Clozapine, Contrast media, Diatrizoate. The full list is on the Alogliptin-metformin page.
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