Interações medicamentosas
Gliclazide + Mecasermin
Gravidade: Grave
Gliclazide and Mecasermin: major interaction.
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Resumo
Mecasermin is recombinant IGF-1 and itself causes hypoglycemia. Combined with a sulfonylurea, the glucose-lowering effect is additive and severe hypoglycemia may occur.
O que esta interação significa em palavras simples
Gliclazide and Mecasermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gliclazide belongs to Endocrine; Mecasermin belongs to Endocrine.
Por que acontece
Additive pharmacodynamic hypoglycemic effects, as IGF-1 has insulin-like activity and gliclazide stimulates insulin secretion.
O que fazer
Monitor blood glucose closely and consider reducing the gliclazide dose. Give mecasermin with or shortly after a meal and teach the patient to recognize and treat hypoglycemia.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Gliclazide
Outras interações de Mecasermin
Perguntas frequentes
Can I take Gliclazide with Mecasermin?
MediHelp rates the interaction as major. Gliclazide and Mecasermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mecasermin is recombinant IGF-1 and itself causes hypoglycemia. Combined with a sulfonylurea, the glucose-lowering effect is additive and severe hypoglycemia may occur.
How serious is the interaction between Gliclazide and Mecasermin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider reducing the gliclazide dose. Give mecasermin with or shortly after a meal and teach the patient to recognize and treat hypoglycemia.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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